CEREBROSPINAL FLUID FINDINGS IN PATIENTS WITH OPTIC NEURITIS
| Autor: | Eeva Nikoskelainen, T. T. Salmi, K. Irjala |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Immunodiffusion Pathology medicine.medical_specialty Optic Neuritis Adolescent Electrophoresis Starch Gel Serum albumin Immunoglobulin G Leukocyte Count Cerebrospinal fluid CSF pleocytosis Albumins medicine Humans Optic neuritis Lymphocytes Child Pleocytosis Serum Albumin CSF albumin Aged Cerebrospinal Fluid Immunoassay biology business.industry Multiple sclerosis Cerebrospinal Fluid Proteins Globulins Complement System Proteins General Medicine Middle Aged medicine.disease Ophthalmology Blood-Brain Barrier Erythrocyte Count biology.protein Female business |
| Zdroj: | Acta Ophthalmologica. 53:105-119 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.1975.tb01143.x |
| Popis: | Cerebrospinal fluid specimens (CSF) from 59 patients with optic neuritis and from 59 age-matched neurological control patients were studied. The patients with optic neuritis showed significantly higher CSF IgG concentrations and a higher frequency of abnormal CSF electrophoresis as compared with the control specimens. Elevated relative IgG values (expressed as percentage of CSF total protein concentration) were noticed in 42%, abnormal electrophoresis in 41%, pleocytosis in 26% and increased total protein concentrations in 29% of CSF specimens from patients with optic neuritis. Thirty patients with an unknown cause of optic neuritis and without any neurological symptoms other than optic neuritis, showed increased relative IgG in 40%, abnormal electrophoresis in 31%, pleocytosis in 33% and increased total protein concentration in 27% of CSF specimens. A reduced serum/CSF albumin ratio was noticed in high frequency in patients with optic neuritis indicating possible blood brain barrier damage. There were, however, 13 patients with optic neuritis and two from the control group with normal serum/CSF albumin ratio but reduced serum/CSF IgG ratio. This finding supports the presumption that part of CSF IgG is produced within the central nervous system (CNS). |
| Databáze: | OpenAIRE |
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