The Evaluation of Interleukin-6 (IL-6) and Tumor Necrosis Factor ^|^alpha;(TNF-^|^alpha;) Level in Peripheral Blood of Patients with Chronic Lower Respiratory Tract Infection
| Autor: | Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Kaoru Hamada, Eiji Kita, Katsuhiro Ueda, Syoji Teramoto, Masahiro Sakamoto, Mori K, Koichi Maeda, Tsujimoto M |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Haemophilus Infections Exacerbation Nutritional Status Inflammation medicine.disease_cause Gastroenterology Haemophilus influenzae Internal medicine Lower respiratory tract infection medicine Humans Pseudomonas Infections Acute-Phase Reaction Interleukin 6 Respiratory Tract Infections Aged Cholinesterase biology Interleukin-6 Tumor Necrosis Factor-alpha Pseudomonas aeruginosa business.industry Albumin General Medicine Middle Aged medicine.disease Chronic Disease biology.protein Female medicine.symptom business Biomarkers |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 71:430-436 |
| ISSN: | 1884-569X 0387-5911 |
| DOI: | 10.11150/kansenshogakuzasshi1970.71.430 |
| Popis: | In the present study, we assessed the serum level of IL-6 and TNF-alpha by ELISA in patients with chronic lower respiratory tract infection. The serum levels of IL-6 and TNF-alpha of patients in acute exacerbation phase are higher than that of in stable phase. We also classified patients in acute exacerbation phase into two groups according to the microorganism of persistent infection. The serum level of IL-6 and TNF-alpha in the patients with persistent infection with Pseudomonas aeruginosa were higher than that with Haemophilus influenzae. Moreover, the serum level of IL-6 and TNF-alpha were found to be related with malnutrition which assessed by clinical indices such as the serum level of albumin and cholinesterase. The present result suggests that IL-6 and TNF-alpha may have relationship with not only inflammation in airway but also indices of nutrition in patients with chronic lower respiratory tract infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|