Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson’s disease
| Autor: | Kathleen L. Poston, Cheshire Hardcastle, Taylor F. Levine, Rosemary Fama, Helen Bronte-Stewart, Varsha Prabhakar, Tilman Schulte, Edith V. Sullivan, Eva M. Müller-Oehring, Ryan Goodcase, Talora Martin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aging
Parkinson's disease Cognitive Neuroscience HIV Infections Disease Neuropsychological Tests 050105 experimental psychology Article 03 medical and health sciences Behavioral Neuroscience Executive Function 0302 clinical medicine Cognition medicine Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Episodic memory Cognitive deficit Aged 05 social sciences Neuropsychology Parkinson Disease Immunosenescence Middle Aged medicine.disease Neuropsychology and Physiological Psychology Cross-Sectional Studies Ageing medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | J Neuropsychol |
| Popis: | Despite the life-extending success of antiretroviral pharmacotherapy in HIV infection (HIV), the prevalence of mild cognitive impairment in HIV remains high. Near-normal life expectancy invokes an emerging role for age–infection interaction and a potential synergy between immunosenescence and HIV-related health factors, increasing risk of cognitive and motor impairment associated with degradation in corticostriatal circuits. These neural systems are also compromised in Parkinson’s disease (PD), which could help model the cognitive deficit pattern in HIV. This cross-sectional study examined three groups, age 45–79 years: 42 HIV, 41 PD, and 37 control (CTRL) participants, tested at Stanford University Medical School and SRI International. Neuropsychological tests assessed executive function (EF), information processing speed (IPS), episodic memory (MEM), visuospatial processing (VSP), and upper motor (MOT) speed and dexterity. The HIV and PD deficit profiles were similar for EF, MEM, and VSP. Although only the PD group was impaired on MOT compared with CTRL, MOT scores were related to cognitive scores in HIV but not PD. Performance was not related to depressive symptoms, socioeconomic status, or CD4(+) T-cell counts. The overlap of HIV-PD cognitive deficits implicates frontostriatal disruption in both conditions. The motor-cognitive score relation in HIV provides further support for the hypothesis that these processes share similar underlying mechanisms in HIV infection possibly expressed with or exacerbated by ageing. |
| Databáze: | OpenAIRE |
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