Single-center evaluation of prognostic factors for thymoma treated by surgery: a retrospective study
| Autor: | Yuyo Suzuki, Satoshi Kamata, Itaru Ishida, Hiroyuki Oura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Complete resection medicine.medical_specialty Neoplasm Residual Thymoma lcsh:Surgery Kaplan-Meier Estimate Postoperative recurrence Single Center Masaoka pathological stage lcsh:RD78.3-87.3 Five-year survival Humans Medicine Stage (cooking) Survival rate Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Retrospective cohort study Thymus Neoplasms General Medicine lcsh:RD1-811 Middle Aged Prognosis Thymectomy medicine.disease Surgery Cardiac surgery Survival Rate Cardiothoracic surgery lcsh:Anesthesiology Female Cardiology and Cardiovascular Medicine business Research Article |
| Zdroj: | Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-8 (2021) Journal of Cardiothoracic Surgery |
| ISSN: | 1749-8090 |
| Popis: | Background This study aimed to retrospectively evaluate the clinical, pathological, and treatment-related factors associated with survival in patients with surgically treated thymomas. Methods Sixty patients with thymomas who underwent treatment at our institution between 2004 and 2015 were included. Survival analysis was performed based on curves that were obtained using the Kaplan–Meier method. The Wilcoxon test was used for all comparisons, and p Results Forty-seven, four, three, four, and two patients presented tumor stages I, II, III, IVa, and IVb (according to the Masaoka classification), respectively, while six, 14, 11, 22, and seven patients had type A, AB, B1, B2, and B3 thymomas, respectively. Furthermore, 53 and eight patients underwent complete resection and required additional resection of adjacent organs, respectively, and no patients died from surgery-related complications. The five-year survival and recurrence-free survival (RFS) rates were 96 and 86%, respectively. The five-year survival rate for all stages was 100% except for those with stage IVb tumors (Masaoka classification); the survival rate for those patients was 0%. Separately, the five-year RFS rates for tumor stages I, II, III, IVa, and IVb were 100, 91, 91, 81, and 71%, respectively. Finally, the five-year survival rates in cases with complete and incomplete resections were 100 and 71%, respectively, indicating that the latter group had a significantly poorer prognosis (p Conclusions These findings suggest that complete resection and the Masaoka pathological stage are significant predictors of prognosis in patients with thymomas. Surgery should aim to achieve complete resection; however, advanced cases may require multimodality therapy. |
| Databáze: | OpenAIRE |
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