Generalized Periodic Discharges With and Without Triphasic Morphology
| Autor: | Ayham Alkhachroum, Macym Rizvi, Haifa Al-Abri, Sarita Maturu, Han Wang, Jennifer Waldron, Guadalupe Fernandez-Baca Vaca, Hans O. Lüders, Alok Sachdeva |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Periodicity Physiology Brain waves Electroencephalography 050105 experimental psychology Statistics Nonparametric 03 medical and health sciences Epilepsy 0302 clinical medicine Triphasic waves Seizures Physiology (medical) Internal medicine medicine Humans 0501 psychology and cognitive sciences In patient Prospective Studies Prospective cohort study Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry 05 social sciences Reproducibility of Results Retrospective cohort study Middle Aged medicine.disease Brain Waves Neurology Cardiology Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 35(2) |
| ISSN: | 1537-1603 |
| Popis: | Purpose Generalized periodic discharges (GPDs) with a triphasic morphology have been associated with nonepileptic encephalopathies. We conducted the study to assess the reliability in which electroencephalographers can differentiate triphasic from nontriphasic periodic discharges and to evaluate for the presence of electroencephalogram and clinical characteristics that are associated with a higher risk of seizures. Methods We studied prospectively 92 patients between May 2016 and February 2017. Each pattern was analyzed by two readers, who were blinded to clinical data. Results The interrater agreement was "substantial" (Kappa 0.67). The following features significantly increased the risk of developing seizures: the absence of triphasic morphology, focality on electroencephalogram, interburst suppression, a history of epilepsy, and an abnormal scan. The "GPD score" includes a history of epilepsy, focality on electroencephalogram, and the absence of triphasic morphology. A GPD score of 0 has 13% risk of seizures, whereas a score of 5 to 6 has a 94% risk. Conclusions Triphasic morphology GPDs confer less risk of seizures when compared with patients with GPDs without triphasic morphology. Features with a higher risk of seizures include focality on electroencephalogram, interburst suppression, a history of epilepsy, and an abnormal scan. The GPD score can be used to assess the risk of developing seizures in patients with GPDs. |
| Databáze: | OpenAIRE |
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