Indinavir Plasma Concentration and Adherence Score Are Codeterminant of Early Virologic Response in HIV-Infected Patients of the APROCO Cohort

Autor:	Panhard X, Lamotte C, François Raffi, Bruno Spire, Dominique Salmon, P. Dellamonica, C. Leport, Gilles Peytavin, Geneviève Chêne, Mentré F, Xavier Duval
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Time Factors Population Cmax HIV Infections Indinavir Observation Drug Administration Schedule Cohort Studies Cmin Antiretroviral Therapy Highly Active Internal medicine Humans Medicine Pharmacology (medical) Prospective Studies Prospective cohort study education Pharmacology education.field_of_study medicine.diagnostic_test business.industry HIV Protease Inhibitors CD4 Lymphocyte Count Treatment Outcome Therapeutic drug monitoring Area Under Curve Multivariate Analysis Immunology Cohort Patient Compliance RNA Viral Female France business Viral load medicine.drug
Zdroj:	Therapeutic Drug Monitoring. 27:63-70
ISSN:	0163-4356
Popis:	To study the respective roles of indinavir concentrations and treatment adherence as predictors of early virologic response, we analyzed the patients of the APROCO cohort treated by indinavir 800 mg TID during the first 4 months. Minimum (Cmin), maximum (Cmax), and the ratio of the measured to expected concentrations (CR) were estimated for each patient at M4, from a population pharmacokinetic analysis of all data. The relationship among virologic success at M4 [plasma HIV RNA (VL)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a374325140e1e1c3aecb413a233cadd https://doi.org/10.1097/00007691-200502000-00013 Zobrazit plný text záznamu