Unilateral, 3D Arm Movement Kinematics Are Encoded in Ipsilateral Human Cortex
| Autor: | Eric C. Leuthardt, Mrinal Pahwa, David T. Bundy, Nicholas Szrama |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Movement Behavioral/Cognitive ipsilateral Kinematics Functional Laterality 03 medical and health sciences 0302 clinical medicine Cortex (anatomy) medicine Humans BCI Electrocorticography Research Articles Neurorehabilitation Brain–computer interface medicine.diagnostic_test Movement (music) business.industry General Neuroscience Motor Cortex Motor control Middle Aged ECoG reach Biomechanical Phenomena Electrodes Implanted 030104 developmental biology medicine.anatomical_structure Arm Female business Neuroscience Psychomotor Performance 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | The Journal of Neuroscience |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.0015-18.2018 |
| Popis: | There is increasing evidence that the hemisphere ipsilateral to a moving limb plays a role in planning and executing movements. However, the exact relationship between cortical activity and ipsilateral limb movements is uncertain. We sought to determine whether 3D arm movement kinematics (speed, velocity, and position) could be decoded from cortical signals recorded from the hemisphere ipsilateral to the moving limb. By having invasively monitored patients perform unilateral reaches with each arm, we also compared the encoding of contralateral and ipsilateral limb kinematics from a single cortical hemisphere. In four motor-intact human patients (three male, one female) implanted with electrocorticography electrodes for localization of their epileptic foci, we decoded 3D movement kinematics of both arms with accuracies above chance. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar, enabling cross-prediction of kinematics between arms. These results clarify our understanding that the ipsilateral hemisphere robustly contributes to motor execution and supports that the information of complex movements is more bihemispherically represented in humans than has been previously understood.SIGNIFICANCE STATEMENTAlthough limb movements are traditionally understood to be driven by the cortical hemisphere contralateral to a moving limb, movement-related neural activity has also been found in the ipsilateral hemisphere. This study provides the first demonstration that 3D arm movement kinematics can be decoded from human electrocorticographic signals ipsilateral to the moving limb. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar. The finding that specific kinematics are encoded in the ipsilateral hemisphere demonstrates that the ipsilateral hemisphere contributes to the execution of unilateral limb movements, improving our understanding of motor control. Additionally, the bihemisheric representation of voluntary movements has implications for the development of neuroprosthetic systems for reaching and for neurorehabilitation strategies following cortical injuries. |
| Databáze: | OpenAIRE |
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