Anaphylaxis to three humanized antibodies for severe asthma: a case study
| Autor: | Koichi Jingo, Jun Ito, Toshihiko Nishioki, Haruhi Takagi, Tomohito Takeshige, Kazuhisa Takahashi, Norihiro Harada, Tomoko Yamada, Tetsuhiko Asao, Masahiro Torasawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty Allergy Humanized antibody Case Report Omalizumab 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine 030212 general & internal medicine Anaphylaxis Mepolizumab Asthma Bronchial thermoplasty business.industry General Medicine Benralizumab medicine.disease Dupilumab Dermatology respiratory tract diseases 030228 respiratory system chemistry business lcsh:RC581-607 medicine.drug |
| Zdroj: | Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology Allergy, Asthma & Clinical Immunology, Vol 16, Iss 1, Pp 1-6 (2020) |
| ISSN: | 1710-1492 1710-1484 |
| Popis: | Background Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare. Case presentation We report the case of a 35-year-old woman with severe asthma, who experienced anaphylaxis following the administration of benralizumab, mepolizumab, and omalizumab, separately. The therapy with biologics was chosen to avoid the repeated use of systemic corticosteroids for asthma exacerbations. The mechanisms underlying anaphylaxis caused by these three biologics remain unclear. The patient’s asthma symptoms and lung function improved after treatment with bronchial thermoplasty. Conclusions To our knowledge, this is the first report of an asthmatic patient developing anaphylaxis after commencement of benralizumab, mepolizumab, and omalizumab therapy. These three biologics should be administered carefully, and patients should be monitored for anaphylaxis. |
| Databáze: | OpenAIRE |
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