Differences in the ability of salbutamol to prevent and reverse LTC4-induced contractions of the guinea-pig isolated trachea: influence of l-serine borate
| Autor: | R. M. Muccitelli, M A Wasserman, Karen A. Wilson, T. J. Torphy, D.W.P. Hay |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Metabolite Guinea Pigs In Vitro Techniques Guinea pig chemistry.chemical_compound Internal medicine Borates medicine Serine Animals Albuterol Respiratory system Pharmacology Leukotriene Chemistry Muscle Smooth In vitro Trachea Endocrinology Mechanism of action Salbutamol SRS-A medicine.symptom medicine.drug Muscle Contraction |
| Zdroj: | European journal of pharmacology. 126(3) |
| ISSN: | 0014-2999 |
| Popis: | In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC 4 -induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC 4 -induced contractions. In addition, the ability of salbutamol pretreatment to prevent LTC 4 -induced contractions was reduced substantially in the presence of l-serine borate, suggesting that the metabolites of LTC 4 (LTD 4 and LTE 4 ) are more sensitive to inhibition by β-adrenoceptor agonists than is LTC 4 itself. |
| Databáze: | OpenAIRE |
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