Two-way coupling between 1D blood flow and 3D tissue perfusion models
| Autor: | Padmos, R.M., Józsa, T.I., El-Bouri, W.K., Závodszky, G., Payne, S.J., Hoekstra, A.G., Paszynski, M., Kranzlmüller, D., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M.A. |
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| Přispěvatelé: | Computational Science Lab (IVI, FNWI) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pressure drop
Chemistry 0206 medical engineering Arterial blood flow 02 engineering and technology Blood flow Brain tissue 020601 biomedical engineering Coupling (electronics) 03 medical and health sciences 0302 clinical medicine Infarct volume Ischaemic stroke Perfusion 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Lecture Notes in Computer Science Lecture Notes in Computer Science-Computational Science – ICCS 2021 Computational Science – ICCS 2021 ISBN: 9783030779665 ICCS (3) Computational Science – ICCS 2021: 21st International Conference, Krakow, Poland, June 16–18, 2021 : proceedings, III, 670-683 Computational Science – ICCS 2021-21st International Conference, Krakow, Poland, June 16–18, 2021, Proceedings, Part III |
| ISSN: | 0302-9743 1611-3349 |
| Popis: | Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupling of a one-dimensional arterial blood flow model and a three-dimensional tissue perfusion model. The two-way coupling occurs through the pial surface, where the pressure drop between the models is captured using a coupling resistance. The two-way coupled model is used to simulate arterial blood flow and tissue perfusion during an acute ischaemic stroke. Infarct volume is estimated by setting a threshold on the perfusion change. By two-way coupling these two models, the effect of retrograde flow and its effect on tissue perfusion and infarct volume can be captured. |
| Databáze: | OpenAIRE |
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