Accelerated lung amino acid release in hyperdynamic septic surgical patients
| Autor: | R. Dean Hautamaki, W. Robert Rout, Wiley W. Souba, Edward M. Copeland, Donald A. Plumley, Tomas D. Martin, Timothy C. Flynn |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Glutamine Glutamic Acid Glutamates Ammonia medicine.artery medicine Humans Postoperative Period Cardiac Output Lung Alanine chemistry.chemical_classification Catabolism business.industry Glutamate receptor Bacterial Infections Surgery Amino acid medicine.anatomical_structure chemistry Anesthesia Catheterization Swan-Ganz Surgical Procedures Operative Pulmonary artery business Flux (metabolism) |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 125(1) |
| ISSN: | 0004-0010 |
| Popis: | • Amino acid flux across the lungs was studied in humans to gain further insight into the altered nitrogen metabolism that characterizes catabolic disease states. Lung flux of glutamine, glutamate, and alanine was determined in three groups of surgical patients with indwelling pulmonary artery catheters: (1) preoperative controls (n 14), (2) postoperative elective general surgical patients (n 10), and (3) hyperdynamic septic surgical patients (n = 17). In controls the lung was an organ of amino acid balance. These exchange rates did not change in general surgical patients. In the septic group, glutamine release by the lung increased markedly from a control value of 0.80 ± 0.99 μmol/kg per minute to 6.80±1.32 μmol/kg per minute. This accelerated release rate was secondary to both an increase in total pulmonary blood flow and an increase in the pulmonary artery-systemic arterial concentration difference. The lung also became an organ of significant alanine release in septic patients. The lung plays an active metabolic role in the processing of amino acids and may be a key regulator in interorgan nitrogen flux after major injury and infection. ( Arch Surg. 1990;125:57-61) |
| Databáze: | OpenAIRE |
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