Lipidomics of Serum and Hippocampus Reveal the Protective Effects of Fermented Soybean Lipid on Rats of Microwave-Induced Cognitive Damage
| Autor: | Guangjie Zhang, Jinpeng Lv, Ying Tian, Jun-Xing Dong, Bin Li, Ziming Xia, Min Li, Qianyu Fu, Hongmei Zhou, Yongzhong Li |
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| Rok vydání: | 2021 |
| Předmět: |
Physiology
Cognitive Neuroscience Phospholipid Hippocampal formation Pharmacology Hippocampus Biochemistry 03 medical and health sciences chemistry.chemical_compound Cognition 0302 clinical medicine Tandem Mass Spectrometry Lipidomics Animals Hippocampus (mythology) Phosphatidylinositol Microwaves 030304 developmental biology 0303 health sciences Chemistry Lipid metabolism Cell Biology General Medicine Lipid Metabolism Rats lipids (amino acids peptides and proteins) Fermentation Soybeans Fermented Foods Sphingomyelin 030217 neurology & neurosurgery Chromatography Liquid |
| Zdroj: | ACS Chemical Neuroscience. 12:2122-2132 |
| ISSN: | 1948-7193 |
| Popis: | Fermented soybean lipids (FSE-C) is an extract enriched in active lipid classes. To explore whether FSE-C can alleviate cognitive damage triggered by the exposure to microwave radiation through regulating lipid metabolism, we employed lipidomic profiling based on a UPLC-MS to investigate differential lipid metabolites in the serum and hippocampus of rats. The results showed that orally administered FSE-C could protect from cognitive damage in microwave-induced rats. Serum lipidomics indicated that FSE-C effectively facilitated the recovery of 43 differential lipid metabolites including 6 phosphatidylcholines (PCs), 5 phosphatidylethanolamines (PEs), 1 phosphatidylinositol, 3 lysophosphatidylcholines (LPCs), 6 lysophosphatidylethanolamines (LPEs), and 22 triglycerides (TGs), which was consistent with the analysis of serum TG levels. Moreover, FSE-C positively coordinated hexacosanoic acid, 2 PCs, 4 sphingomyelins (SMs), and 11 TGs, through the hippocampal lipidomics. Collectively, these findings suggested that phospholipid and TG metabolisms were significantly modified in microwave-exposed rats. TGs may be regarded as potential biomarkers to further investigate and evaluate the roles and functions of FSE-C on the attenuation of cognitive damage induced by microwave radiation. |
| Databáze: | OpenAIRE |
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