Major reduction of NKT cells in patients with severe COVID-19 pneumonia
| Autor: | Miriam Lichtner, Giuseppe La Torre, Parni Nijhawan, Fabio Mengoni, Francesco Cogliati Dezza, Claudio Maria Mastroianni, Valentina Perri, Maria Rosa Ciardi, Claudia D'Agostino, Giulia Savelloni, Patrizia Pasculli, Maria Antonella Zingaropoli |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male CD3 Complex Coronavirus disease 2019 (COVID-19) CD56bright Immunology Cell macromolecular substances Disease Flow cytometry 03 medical and health sciences 0302 clinical medicine Immunophenotyping analysis Antigens CD Full Length Article Immunology and Allergy Medicine Humans In patient Aged Aged 80 and over medicine.diagnostic_test business.industry SARS-CoV-2 COVID-19 Middle Aged Flow Cytometry Natural killer T cell Acquired immune system medicine.disease CD56 Antigen Pneumonia 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Natural Killer T-Cells Female cd56bright cd56dim flow cytometry immunophenotyping analysis sars-cov-2 business CD56dim 030215 immunology |
| Zdroj: | Clinical Immunology (Orlando, Fla.) Clinical Immunology |
| ISSN: | 1521-7035 |
| Popis: | Background NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. Methods We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Results Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. Conclusions The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset. Graphical abstract Unlabelled Image Highlights • High percentages of NK CD57+ cells and CD56dimNK cells in COVID-19 subjects • Low percentages of CD56bright and NKT cells in COVID-19 subjects • Severe COVID-19 pneumonia and NKT cell reduction were independently associated |
| Databáze: | OpenAIRE |
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