Comparison of small biopsy specimens and surgical specimens for the detection of EGFR mutations and EML4-ALK in non-small-cell lung cancer
| Autor: | Qiu Yan He, Shuang Liu, Yong Guang Tao, Jianhua Zhou, Chun Yan Fu, Wei Zhu, De Sheng Xiao, Can Lu, Yong Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Lung Neoplasms Adolescent Oncogene Proteins Fusion EGFR Biopsy EML4-ALK Gene mutation medicine.disease_cause 03 medical and health sciences Young Adult 0302 clinical medicine hemic and lymphatic diseases Carcinoma Non-Small-Cell Lung medicine Carcinoma Anaplastic lymphoma kinase Humans Epidermal growth factor receptor Lung cancer Aged Aged 80 and over medicine.diagnostic_test biology business.industry Cancer Middle Aged medicine.disease small biopsy specimens surgical specimens ErbB Receptors 030104 developmental biology Oncology 030220 oncology & carcinogenesis Mutation biology.protein non-small-cell lung carcinoma Female Carcinogenesis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // DeSheng Xiao 1, 2 , Can Lu 1, 2 , Wei Zhu 1, 2 , QiuYan He 1, 2 , Yong Li 1, 2 , ChunYan Fu 1, 2 , JianHua Zhou 1, 2 , Shuang Liu 6 , YongGuang Tao 3, 4, 5, 6 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410078 China 2 Department of Pathology, School of Basic Medicine, Central South University, Changsha, Hunan 410078 China 3 Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078 China 4 Key Laboratory of Carcinogenesis and Cancer Invasion (Central South University), Ministry of Education, Hunan, 410078 China 5 Key Laboratory of Carcinogenesis (Central South University), Ministry of Health, Hunan, 410078 China 6 Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 China Correspondence to: YongGuang Tao, email: taoyong@csu.edu.cn Keywords: EGFR, EML4-ALK, small biopsy specimens, surgical specimens, non-small-cell lung carcinoma Received: March 29, 2016 Accepted: May 29, 2016 Published: June 14, 2016 ABSTRACT Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusion genes represent novel oncogenes that are associated with non–small-cell lung cancers (NSCLC). The feasibility of detecting EGFR mutations and ALK fusion genes in small biopsy specimens or surgical specimens was determined. Of the 721 NSCLC patients, a total of 305 cases were positive for EGFR mutations (42.3%). The rate of EGFR mutations in women was significantly higher than that in men. Histologically, the EGFR mutation rate in adenocarcinomas was significantly higher than that in squamous cell carcinomas. No difference in the EGFR mutation rate was observed between surgical specimens (42.1%) and small biopsy specimens (42.4%), which indicated that the EGFR mutation ratios in surgical specimens and small biopsy specimens were not different. In 385 NSCLC patients, 26 cases were positive for EML4-ALK (6.8%). However, 11.7% of the surgical specimens were EML4-ALK-positive, whereas the positive proportion in the small biopsy specimens was only 4.7%, which indicated that EML4-ALK-positive rate in the surgical specimens was significantly higher than that in the small biopsy specimens. Detection of EGFR gene mutations was feasible in small biopsy specimens, and screening for EML4-ALK expression in small biopsy specimens can be used to guide clinical treatments. |
| Databáze: | OpenAIRE |
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