Integrated positron-emission tomography for nodal staging in lung cancer
| Autor: | Hyun Ju Lee, Chang Hyun Kang, Joohyun Kim, Hyun Joo Lee, Won Jun Kang, Young Tae Kim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Biopsy Sensitivity and Specificity Mediastinoscopy Pneumonectomy Predictive Value of Tests Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans False Positive Reactions Stage (cooking) Lung cancer False Negative Reactions Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Functional imaging Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Lymph Node Excision Surgery Female Radiology Tomography Lymph Nodes Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed |
| Zdroj: | Asian cardiovascularthoracic annals. 17(6) |
| ISSN: | 1816-5370 |
| Popis: | As lymph node metastasis is the most important factor determining the surgical outcome of lung cancer, we evaluated the accuracy and clinical usefulness of functional imaging with integrated positron-emission tomography and computed tomography in nodal staging of non-small-cell lung cancer. Between October 2003 and August 2004, 43 newly diagnosed patients underwent curative surgical resection or mediastinoscopic nodal biopsy after chest computed tomography as well as whole-body functional imaging for clinical staging. Based on histopathologic findings in the lymph nodes, we compared the diagnostic usefulness of computed tomography and functional imaging. Twenty-two patients were N0 stage, 6 were N1, 11 were N2, and 4 were N3. Although functional imaging seemed to be superior for evaluation of N2 nodes, there were no significant differences in the sensitivity, specificity, positive-predictive value, negative-predictive value, or accuracy. The situation was similar for N1 nodes, and there were no significant differences except for the false-negative rate. High false-positive and negative-rates for N2 lymph nodes suggest that functional imaging should not replace mediastinoscopy. |
| Databáze: | OpenAIRE |
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