Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations
| Autor: | Ji-Eun Kim, Min Whan Jung, Jongchan Park, Jung Won Bae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Delayed response Computer science Action Potentials Prefrontal Cortex lcsh:Medicine behavioral disciplines and activities Article Mice 03 medical and health sciences Neural activity 0302 clinical medicine Reaction Time Delay Duration Animals Premovement neuronal activity Predictability Prefrontal cortex lcsh:Science Neurons Multidisciplinary Working memory lcsh:R Memory Short-Term 030104 developmental biology nervous system Cortex lcsh:Q Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-52017-8 |
| Popis: | Diverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1–7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration. |
| Databáze: | OpenAIRE |
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