Amantadine in Parkinson's disease: lymphocyte subsets and IL-2 secreting T cell precursor frequencies
| Autor: | Ch. Wöber, V Schönborn, S Panzer, G.G Tribl, Lüder Deecke, Thomas Brücke |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Interleukin 2
Male Aging Parkinson's disease medicine.drug_class CD3 T cell T-Lymphocytes Biochemistry Antiparkinson Agents Endocrinology Immune system Genetics medicine Amantadine Humans Lymphocyte Count Molecular Biology Aged Aged 80 and over biology Stem Cells Parkinson Disease Cell Biology Middle Aged medicine.disease Lymphocyte Subsets medicine.anatomical_structure Immunology biology.protein Interleukin-2 Female Antiviral drug CD8 medicine.drug |
| Zdroj: | Experimental gerontology. 36(10) |
| ISSN: | 0531-5565 |
| Popis: | The antiviral drug amantadine, that is effective in idiopathic Parkinson's disease (PD), may affect the composition and function of peripheral blood lymphocytes. In an explorative study, we therefore compared lymphocyte subpopulations and IL-2 secreting T cell precursors frequencies (HTLp-frequencies) in 15 PD patients without amantadine and six patients on long-term treatment. Five patients were investigated before and three months after the start of treatment. Group comparisons for long-term amantadine treatment showed no differences in subpopulations of B-, T-, and NK cells, and HTLp-frequencies. However, three months after initiation of treatment we noted in all five patients an increase of CD3+CD4+ and decrease of CD3+CD8+ cells, associated with an increase of the CD3+CD4+/CD3+CD8+ ratio. These changes had no effect on the HTLp-frequencies. Thus, at least for a short period of time, amantadine improves the T cell mediated immune system in PD patients. |
| Databáze: | OpenAIRE |
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