Association of persistent organic pollutants with sensorimotor neuropathy in participants with and without diabetes or prediabetes: Results from the population-based KORA FF4 study
Autor: | Alexandra Schneider, Christian Herder, Kathrin Wolf, Michael Roden, Karl-Werner Schramm, Brenda Bongaerts, Maximilian Schwarz, Bernhard Henkelmann, Wolfgang Rathmann, Annette Peters, Dan Ziegler |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Population Type 2 diabetes 010501 environmental sciences Logistic regression 01 natural sciences Prediabetic State 03 medical and health sciences Persistent Organic Pollutants 0302 clinical medicine Diabetes mellitus Internal medicine medicine Hydrocarbons Chlorinated Humans 030212 general & internal medicine Prediabetes education 0105 earth and related environmental sciences education.field_of_study business.industry Public Health Environmental and Occupational Health medicine.disease Obesity Polychlorinated Biphenyls Cross-Sectional Studies Diabetes Mellitus Type 2 Environmental Pollutants business Polyneuropathy Body mass index Diabetes Kora Peripheral Polyneuropathy Persistent Organic Pollutant |
Zdroj: | Int. J. Hyg. Environ. Health 235:113752 (2021) |
ISSN: | 1618-131X |
Popis: | Background Concentrations of persistent organic pollutants (POPs) have been associated with an increased type 2 diabetes (T2D) risk. It remains unclear whether POPs are also associated with the risk of diabetes complications including neuropathy and evidence on this topic is scarce. We aimed to investigate the hypothesis that low-dose background concentrations of POPs were positively associated with distal sensorimotor polyneuropathy (DSPN). Methods This cross-sectional study was based on data from the second follow-up (FF4, 2013–2014, N = 2279) of the population-based KORA S4 study (Augsburg, Germany). The study sample consisted of 200 participants, including four groups of 50 persons each with known T2D, prediabetes, newly diagnosed diabetes, and normal glucose tolerance (NGT) based on an oral glucose tolerance test. We analyzed the association of six most abundant serum concentrations of POPs, including polychlorinated biphenyls (PCBs) as well as organochlorine (OC) pesticides, with DSPN by multivariable logistic regression adjusted for age, sex, glycaemic status, body mass index, physical activity, smoking and alcohol consumption. We assessed effect modification by age, sex, glycaemic status and obesity and conducted two-pollutant models to check the robustness of the estimates. Results For all pollutants, the main models indicated no significant association of having DSPN but pointed to rather decreased odds for DSPN. Two-pollutant models supported these findings, though only the association between the combination of PCB-138 and beta-hexachlorocyclohexane (β-HCH) (OR: 0.59; 95% CI: 0.35–0.99) with DSPN became significant. No effect modification was found by age, sex, glycaemic status and obesity. Conclusion Low-dose concentrations of POPs were not associated with increased odds of having DSPN in T2D, prediabetes and NGT. |
Databáze: | OpenAIRE |
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