Gene expression profiling indicates that immunohistochemical expression of CD40 is a marker of an inflammatory reaction in the tumor stroma of diffuse large B-cell lymphoma

Autor:	Johan Linderoth, Eva Cavallin-Ståhl, Patrik Edén, Karin Rydström, Mats Ehinger, Mats Jerkeman, Patrick Joost
Rok vydání:	2012
Předmět:	CD4-Positive T-Lymphocytes Male Cancer Research Pathology medicine.medical_specialty CD8-Positive T-Lymphocytes Biology Receptors Urokinase Plasminogen Activator Proinflammatory cytokine Cohort Studies Stroma Biglycan Biomarkers Tumor medicine Humans CD40 Antigens Inflammation Gene Expression Profiling Macrophages Proteolytic enzymes Hematology Integrin alphaV Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Lymphoma Gene expression profiling Oncology Cancer research Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma
Zdroj:	Leukemia & Lymphoma. 53:1764-1768
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428194.2012.666541
Popis:	Immunohistochemical expression of CD40 is seen in 60-70% of diffuse large B-cell lymphoma (DLBCL) and is associated with a superior prognosis. By using gene expression profiling we aimed to further explore the underlying mechanisms for this effect. Ninety-eight immunohistochemically defined CD40 positive or negative DLBCL tumors, 63 and 35 respectively, were examined using spotted 55K oligonucleotide arrays. CD40 expressing tumors were characterized by up-regulated expression of genes encoding proteins involved in cell-matrix interactions: collagens, integrin αV, proteoglycans and proteolytic enzymes, and antigen presentation. Immunohistochemistry confirmed that CD40 positive tumors co-express the proinflammatory proteoglycan biglycan (p = 0.005), which in turn correlates with the amount of infiltrating macrophages and CD4 and CD8 positive T-cells. We postulate that immunohistochemical expression of CD40 mainly reflects the inflammatory status in tumors. A high intratumoral inflammatory reaction may correlate with an increased autologous tumor response, and thereby a better prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2648bafd45863c423ad9e25554dfa0 https://doi.org/10.3109/10428194.2012.666541 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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