Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life
| Autor: | Francesc Colom, PATRICIA VEGA PEREZ, Gonzalo Daniel Galván, María Mayoral, Ramón Landin-Romero, ANGELA IBAÑEZ, Marta Rapado-Castro, Virginia Soria, Patricia Correa Ghisays, Vicent Balanzá-Martínez, Ana María González-Pinto, Barbara Segura, Jose Menchon, Inmaculada Fuentes Durá, ESTHER JIMENEZ, Benedikt L Amann, Pilar A. Saiz, Rafael Tabares-Seisdedos, Jose Luis Ayuso-Mateos, Anabel Martinez-Aran, Adriane Rosa, Caterina del Mar Bonnín, Susana Al-Halabí, JESSICA MERCHÁN NARANJO, Paz Garcia-Portilla, Covadonga Martínez Díaz-Caneja, Jose Sanchez-Moreno, Julio Bobes, Brisa Solé, Analucia Alegria, Eduard Vieta, Sara Barbeito Resa, Silvia Alonso-Lana |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Bipolar Disorder Social Skills 03 medical and health sciences Executive Function 0302 clinical medicine Quality of life (healthcare) Visual memory Cognitive Reserve medicine Humans Cognitive Dysfunction Cognitive skill Bipolar disorder Cognitive reserve Working memory Cognition Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Quality of Life Female Psychology Psychosocial 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Acta psychiatrica Scandinavica. 133(5) |
| ISSN: | 1600-0447 |
| Popis: | Objective Cognitive reserve (CR) is a concept that was postulated as a protective factor for some clinical symptoms after the observation that there is not a direct relationship between the degree of brain damage and its clinical manifestation. This study aimed to explore the association between CR and the main outcomes in bipolar disorder (BD): cognitive functions, psychosocial functioning and perceived quality of life. Method A sample of 224 euthymic bipolar patients was assessed with a neuropsychological battery, the Functioning Assessment Short Test and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). CR was calculated through three proxies: estimated premorbid Intelligent Quotient, educational level and occupational attainment. Relationships between CR and cognitive functions, psychosocial functioning and quality of life were assessed by multiple linear regression models. Results Higher CR was associated with better cognitive functioning (P < 0.001 in processing speed, working memory, verbal and visual memory, and executive function; P = 0.026 in attention) and better psychosocial functioning (P = 0.008). For quality of life, CR was positively associated with the physical component of the SF-36 (P = 0.016) but negatively associated with the mental component (P = 0.004). Conclusion The results suggest that CR may play an important role in the course and prognosis of bipolar patients and it should be considered in both clinical and research settings related to BD. |
| Databáze: | OpenAIRE |
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