Base-Catalyzed Feedback in the Urea−Urease Reaction
| Autor: | Magdalena M. Wrobel, Gang Hu, John A. Pojman, Stephen K. Scott, Annette F. Taylor |
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| Rok vydání: | 2010 |
| Předmět: |
Bistability
Urease Base (chemistry) Kinetic energy Catalysis chemistry.chemical_compound Biomimetics Enzyme Stability Materials Chemistry Urea Physical and Theoretical Chemistry Feedback Physiological chemistry.chemical_classification biology Chemistry Hydrogen-Ion Concentration Biocompatible material Surfaces Coatings and Films Kinetics Hysteresis Models Chemical Chemical engineering Biocatalysis biology.protein Protein Binding |
| Zdroj: | The Journal of Physical Chemistry B. 114:14059-14063 |
| ISSN: | 1520-5207 1520-6106 |
| DOI: | 10.1021/jp106532d |
| Popis: | The bell-shaped rate-pH curve coupled to production of base in the urea-urease reaction was utilized to give feedback-driven behavior: an acid-to-base pH clock (a kinetic switch), bistability and hysteresis between an acid/base state when the initial pH was adjusted by a strong acid, and aperiodic pH oscillations when the initial pH was adjusted by a weak acid in an open reactor. A simple model of the reaction reproduced most of the experimental results and provided insight into the role of self-buffering in the dynamics. This reaction suggests new possibilities in the development of biocompatible feedback to couple to pH-sensitive processes for bioinspired applications in medicine, engineering, or materials science. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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