Tumor-Based Genetic Testing and Familial Cancer Risk
| Autor: | Andrea Forman, Jilliane Sotelo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Somatic cell Genetic counseling Genetic Counseling Bioinformatics General Biochemistry Genetics and Molecular Biology Germline 03 medical and health sciences 0302 clinical medicine Germline mutation Neoplasms Cancer screening medicine Humans Genetic Predisposition to Disease Genetic Testing Germ-Line Mutation Genetic testing medicine.diagnostic_test business.industry Cancer treatment 030104 developmental biology 030220 oncology & carcinogenesis Female Familial Cancer business Perspectives |
| Zdroj: | Cold Spring Harb Perspect Med |
| ISSN: | 2157-1422 |
| DOI: | 10.1101/cshperspect.a036590 |
| Popis: | As genetic testing on somatic tumor tissue becomes a more routine part of personalized cancer treatment, a growing opportunity arises to identify hereditary germline variants within those results. These germline results can affect future cancer screening for both patients and their family members. Finding this germline information can be complicated as a result of differences between somatic and germline testing processes, nomenclature, and outcome goals (e.g., treatment impact). The goal of this review is to highlight differences between somatic and germline testing and outline a potential guide to allow for appropriate clinical interpretation of somatic testing results in order to better facilitate genetic counseling referrals and confirmatory germline testing. |
| Databáze: | OpenAIRE |
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