Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis
| Autor: | G. Veneri, Gianni Zoccatelli, Roberto Chignola, Silvia Mosconi, Corrado Rizzi, G. Andrighetto, Gaetano Bissoli, Federica Mainente, Giorgia Padovani, Chiara Dalla Pellegrina, Angelo Dal Belin Peruffo |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Fibrosarcoma phenolics Transplantation Heterologous Apoptosis Biology Peripheral blood mononuclear cell selective apoptosis Oenothera biennis Mice chemistry.chemical_compound Phenols Gallic Acid Animals Humans Gallic acid Mice Inbred BALB C Dose-Response Relationship Drug Plant Extracts Biological activity Transplantation Kinetics Oncology Biochemistry chemistry Cell culture Caspases anti-tumor activity Female Caco-2 Cells Multiple Myeloma |
| Zdroj: | Cancer Letters. 226:17-25 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2004.11.033 |
| Popis: | A phenolic fraction purified form defatted seeds of Oenothera biennis promoted selective apoptosis of human and mouse bone marrow-derived cell lines following first-order kinetics through a caspase-dependent pathway. In non-leukemia tumour cell lines, such as human colon carcinoma CaCo(2) cells and mouse fibrosarcoma WEHI164 cells, this fraction inhibited (3)H-thymidine incorporation but not cell death or cell cycle arrest. Human peripheral blood mononuclear cells showed low sensitivity to treatment. Single bolus injection of the phenolic fraction could delay the growth of established myeloma tumours in syngeneic animals. HPLC and mass spectrometry analysis revealed that the fraction contains gallic acid. However, the biological activity of the fraction differs from the activity of this phenol and hence it should be attributed to other co-purified molecules which remain still unidentified. |
| Databáze: | OpenAIRE |
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