Detection of trace metallic elements in oral lichenoid contact lesions using SR-XRF, PIXE, and XAFS
| Autor: | Chiya Numako, Tadahide Noguchi, Kazuo Komiyama, Tomoko Sugiyama, Yoshiyuki Mori, Motohiro Uo, Takahiro Wada, Daisuke Omagari, Yoshinori Jinbu, Serika Miyazaki, Mikio Kusama |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multidisciplinary Chemistry Dental alloys Mouth Mucosa Negative control medicine.disease Article X-ray absorption fine structure Trace Elements Metal stomatognathic diseases stomatognathic system visual_art visual_art.visual_art_medium medicine Humans Oral lichen planus Female Dental Alloys Lichen Planus Oral |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Oral lichen planus (OLP) and oral lichenoid contact lesions (OLCL) are chronic inflammatory mucocutaneous reactions with a risk of malignant transformation that alter the epithelium. OLP and OLCL have similar clinical and histopathological features and it is difficult to distinguish one from the other. Metallic restorations are suspected to generate OLCLs. Trace metal analysis of OLCL specimens may facilitate the discrimination of symptoms and identification of causative metallic restorations. The purpose of this study was to assess OLCL tissue samples for the prevalence of metallic elements derived from dental restorations and to discriminate OLCL from OLP by using synchrotron radiation-excited X-ray fluorescence analysis (SR-XRF), particle-induced X-ray emission (PIXE) and X-ray absorption fine structure (XAFS). Typical elements of dental materials were detected in the OLCL, whereas no obvious element accumulation was detected in OLP and negative control specimens. The origin of the detected metallic elements was presumed to be dental alloys through erosion. Therefore, our findings support the feasibility of providing supporting information to distinguish OLCL from OLP by using elemental analysis. |
| Databáze: | OpenAIRE |
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