Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
| Autor: | Eva Ardanaz, Guillem Pera, M-D Chirlaque, S. Rinaldi, D. Zilis, Tobias Pischon, Stefano Landi, Carine Biessy, Bertrand Tehard, Carmen Martinez-Garcia, Timothy J. Key, Elio Riboli, J. Linseisen, Kay-Tee Khaw, Veronique Chajes, Jenny Chang-Claude, Stéphanie Monnier, C. H. van Gils, Dimitrios Trichopoulos, H. B. Bueno-De-Mesquita, Catherine Boillot, Paolo Vineis, J. R. Quirós, Nerea Larrañaga, Teresa Norat, Naomi E. Allen, James D. McKay, Petra H. Lahmann, Franco Berrino, P. H. M. Peeters, F. Clavel-Chapelon, Federico Canzian, Laure Dossus, Sheila Bingham, Antonia Trichopoulou, Rebecca J. Cleveland, R. Tumino, Nadia Slimani, D. Palli, Rudolf Kaaks |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Candidate gene medicine.medical_treatment IGFBP3 Single-nucleotide polymorphism Breast Neoplasms Biology Polymorphism Single Nucleotide 03 medical and health sciences Prostate cancer Insulin-like growth factor single nucleotide polymorphisms 0302 clinical medicine Breast cancer breast cancer Risk Factors Internal medicine medicine Humans ddc:610 Risk factor IGFALS Insulin-Like Growth Factor I 030304 developmental biology Aged 0303 health sciences Genetics and Genomics IGFBP-3 IGFBP-1 Middle Aged medicine.disease 3. Good health European Prospective Investigation into Cancer and Nutrition IGF-I Insulin-Like Growth Factor Binding Proteins Endocrinology Insulin-Like Growth Factor Binding Protein 3 030220 oncology & carcinogenesis Case-Control Studies Female |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians. |
| Databáze: | OpenAIRE |
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