Glycated hemoglobin in camel: Minimal correlation with blood glucose level
| Autor: | Senaidy Al Abdulrahman, Nayyar Rabbani, S Mohammed Elrobh, D Mohammad Bazzi, Ajamaluddin Malik, Hasan Al Mohammed, Mushari Quazani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system camel Chemistry Glycated Hb Normal hemoglobin modeling Human values hemoglobin General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology lcsh:Biology (General) Glycation blood Internal medicine High glucose medicine glycation Hemoglobin Glycated hemoglobin glucose General Agricultural and Biological Sciences lcsh:QH301-705.5 |
| Zdroj: | Archives of Biological Sciences, Vol 65, Iss 3, Pp 911-917 (2013) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Glucose and glycated hemoglobin (Hb) in the blood of camel (Camelus dromedarius) and cow (Bos taurus) were analyzed and compared with human values. Camel displayed high blood glucose concentration (9.7±2.8 mM) but a low level of glycated-Hb (3.4± 0.23%).Cow blood samples did not show sufficient variations in glucose concentrations (5.7±0.73 mM) or glycated Hb levels (3.2± 0.11%) compared to human values. The low glycation of camel Hb at higher glucose concentrations suggest that certain factors protect the Hb from glycation at high glucose concentrations. Camel Hb also exhibited a higher electrophoretic mobility than normal hemoglobin of human or cow. Camel Hb migrated at a rate corresponding to that of human Hb-C. Bioinformatics tools were used to explore the biochemical basis for the difference in camel Hb migratory position and its apparent resistance to glycation. |
| Databáze: | OpenAIRE |
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