Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV
| Autor: | Paulo Roberto Palma Urbano, Isabel Cristina Lopes dos Santos, Maria Cristina Domingues da Silva Fink, Regina Célia de Menezes Succi, Alessandra Aparecida Machado, Cláudio Sérgio Pannuti, Aída de Fátima Thomé Barbosa Gouvêa, Fabiana Bononi do Carmo, Clarisse Martins Machado, Suenia Vasconcelos Beltrão, Daisy Maria Machado |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Male lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 viruses JC virus lcsh:QR1-502 Urine Biology medicine.disease_cause Polymerase Chain Reaction lcsh:Microbiology Excretion Cohort Studies Young Adult BK virus medicine Humans Polyomavirus Infections child AIDS-Related Opportunistic Infections Progressive multifocal leukoencephalopathy Infant virus diseases Viral Load medicine.disease Virology urine CD4 Lymphocyte Count Tumor Virus Infections Case-Control Studies Child Preschool adolescent DNA Viral Coinfection HIV-1 Female Viral load |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 106, Iss 8, Pp 931-935 (2011) Memórias do Instituto Oswaldo Cruz, Volume: 106, Issue: 8, Pages: 931-935, Published: DEC 2011 |
| ISSN: | 1678-8060 |
| Popis: | The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. |
| Databáze: | OpenAIRE |
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