Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana
| Autor: | Amélia T. Henriques, Krissie D. Soares, Miriam Anders Apel, Natally S.B. Toson, Sérgio Augusto de Loreto Bordignon, Marí Castro Santos, M.C.B. Pimentel, Betina M. Beltrame, Andreas Sebastian Loureiro Mendez |
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| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Angiotensins Neutrophils medicine.drug_class Anti-Inflammatory Agents Angiotensin-Converting Enzyme Inhibitors Bioengineering 01 natural sciences Biochemistry Anti-inflammatory Cuphea chemistry.chemical_compound medicine Animals Molecular Biology Miquelianin Antihypertensive Agents chemistry.chemical_classification biology Traditional medicine Plant Extracts 010405 organic chemistry Polyphenols Chemotaxis General Chemistry General Medicine biology.organism_classification In vitro Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Enzyme chemistry Polyphenol Molecular Medicine Composition (visual arts) |
| Zdroj: | Chemistry & Biodiversity. 18 |
| ISSN: | 1612-1880 1612-1872 |
| Popis: | The present study investigates the chemical composition, anti-inflammatory, and antihypertensive activities, in vitro, from extracts of Cuphea lindmaniana and Cuphea urbaniana leaves. The extraction was performed ultrasound-assisted, and UHPLC/MS analysis was in positive mode ionization. The anti-inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001-10 μg/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin-converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100 % of the neutrophil migration, in vitro, in most concentrations. The ACE-inhibition presented results ranging from 19.58 to 22.82 %. In conclusion, C. lindmaniana and C. urbaniana extracts contain a rich diversity of flavonoids and display in vitro anti-inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions. |
| Databáze: | OpenAIRE |
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