Comparing Two Imaging Methods for Follow-Up of Lung Cancer Treatment: A Randomized Pilot Study
Autor: | Franco Gambazzi, Sereina M. Graber, Sarosh Irani, Oliver S. Springer, Bettina Boerner, Wolf-Dieter Janthur, Juerg Heuberger, Roland Zweifel, Lukas D. Frey, Matthias Bruehlmeier, Gabrielo M. Tini |
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Rok vydání: | 2019 |
Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Pilot Projects 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Fluorodeoxyglucose F18 law Carcinoma Non-Small-Cell Lung Carcinoma Humans Medicine Combined Modality Therapy Prospective Studies Lung cancer Prospective cohort study Radiologic Finding Aged business.industry Incidence Incidence (epidemiology) Reproducibility of Results Middle Aged Prognosis medicine.disease Confidence interval 030228 respiratory system Positron-Emission Tomography Female Surgery Radiology Neoplasm Recurrence Local Radiopharmaceuticals Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Switzerland Follow-Up Studies |
Zdroj: | The Annals of Thoracic Surgery. 107:430-435 |
ISSN: | 0003-4975 |
Popis: | Background Scientific data on the image modality to be used in postcurative treatment surveillance of non-small cell lung cancer patients are scarce. This prospective randomized pilot trial compared the performance of integrated 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) and contrast-enhanced computed tomography (CE-CT). Methods After termination of curative-intent treatment, patients were randomly assigned to the PET-CT or the CE-CT group. Imaging was performed every 6 months for 2 years. If suspicious radiologic findings were detected or patients became symptomatic, a diagnostic workup was initiated. Sensitivity, specificity, and positive predictive value for detecting cancer recurrence were calculated for both imaging procedures. Results The study enrolled 96 patients. In 14 of 50 patients (28%) in the PET-CT group and in 14 of 46 patients (30%) in the CE-CT group, a suspicious radiologic finding was confirmed as cancer recurrence after diagnostic workup. False-positive findings were detected in 11 patients (22%) of the PET-CT group and in 8 patients (17%) of the CE-CT group. The sensitivity, specificity, and positive predictive value for detecting cancer recurrence (95% confidence interval) were 0.88 (0.62 to 0.98), 0.62 (0.42 to 0.79), and 0.56 (0.35 to 0.76) for PET-CT and 0.93 (0.68 to 1.00), 0.72 (0.53 to 0.87), and 0.64 (0.41to 0.83) for CE-CT, respectively. Conclusions The results of our study suggest that PET-CT is not superior to CE-CT in detecting cancer recurrence during 2 years after curative-intent treatment of non-small cell lung cancer. |
Databáze: | OpenAIRE |
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