Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania
| Autor: | Teofana Otilia Bizerea-Moga, Tudor Moga, Laura Pitulice, Otilia Bizerea-Spiridon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent media_common.quotation_subject Physiology chemistry.chemical_element 030209 endocrinology & metabolism Fertility Serum selenium Article Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors age stratification Medicine Humans oxidative stress young population TX341-641 selenium media_common Aged Retrospective Studies chemistry.chemical_classification Aged 80 and over fertility 030109 nutrition & dietetics Nutrition and Dietetics Reproductive function business.industry Romania Nutrition. Foods and food supply Glutathione peroxidase Age Factors Middle Aged human serum chemistry Age stratification Female Reproduction business Selenium Food Science Cohort study |
| Zdroj: | Nutrients, Vol 13, Iss 1497, p 1497 (2021) Nutrients Volume 13 Issue 5 |
| ISSN: | 2072-6643 |
| Popis: | Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16–89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 μg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16–35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 μg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function. |
| Databáze: | OpenAIRE |
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