Alcohol ingestion lowers supine blood pressure, causes splanchnic vasodilatation and worsens postural hypotension in primary autonomic failure
| Autor: | S. Maule, T. Thomaides, Christopher J. Mathias, D. V. Pavitt, K. Ray Chaudhuri |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Glucose Male Cardiac output Supine position Epinephrine Blood Pressure Vasodilation Hypotension Orthostatic Norepinephrine Heart Rate Mesenteric Artery Superior Humans Insulin Medicine Pure autonomic failure Aged Orange juice Ethanol business.industry Hemodynamics Blood flow Middle Aged medicine.disease Forearm Blood pressure Autonomic Nervous System Diseases Thumb Neurology Regional Blood Flow Anesthesia Female Neurology (clinical) Hypotension Splanchnic business |
| Zdroj: | Journal of Neurology. 241:145-152 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/bf00868341 |
| Popis: | Patients with pure autonomic failure (PAF) and multiple system atrophy (MSA) may complain of feeling light-headed after alcohol ingestion particularly on assumption of the upright posture. The reasons for this have not been investigated. We therefore studied the effects of oral alcohol (40% vodka in sugar-free orange juice) and placebo (juice only) on the systemic and regional (including superior mesenteric artery, SMA) blood flow in nine patients with PAF and six patients with MSA. After alcohol, there was a fall in supine blood pressure (BP) and vasodilatation in the SMA but no change in cardiac output, or forearm muscle and cutaneous blood flow in either PAF or MSA; BP fell further during head-up tilt with no changes in levels of plasma catecholamines. After placebo, there were no changes while supine. We conclude that alcohol lowers supine BP and dilates the SMA with no change in muscle or cutaneous blood flow. Alcohol also enhances the fall in BP during head-up tilt. This may explain the symptoms experienced by PAF and MSA patients after alcohol. |
| Databáze: | OpenAIRE |
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