Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets : the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule

Autor: Herbert P.M. Brok, Antonio Uccelli, Natasja G. de Groot, Bert A. 't Hart, Nicole Kerlero de Rosbo, Elisabetta Capello, Ronald E. Bontrop, Avraham Ben-Nun, Luca Roccatagliata, Gianluigi Mancardi, Klaas Nicolay, Jon D. Laman
Přispěvatelé: Immunology
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Male
Animals
Antigen Presentation
Autoantibodies
biosynthesis
Callithrix
Cell Line
Encephalomyelitis
Autoimmune
Experimental
etiology/immunology/pathology
Epitopes
T-Lymphocyte
immunology/metabolism
Female
Histocompatibility Antigens Class II
immunology/metabolism
Humans
Immunization
Injections
Intradermal
Lymphocyte Activation
Male
Myelin Basic Proteins
administration /&/ dosage/immunology
Myelin Proteins
Myelin-Associated Glycoprotein
administration /&/ dosage/immunology
Peptide Fragments
immunology/metabolism
T-Lymphocyte Subsets
immunology
Epitopes
T-Lymphocyte
Lymphocyte Activation
Epitope
Myelin
Epitopes
Myelin Basic Proteins
T-Lymphocyte Subsets
immune system diseases
Immunology and Allergy
Encephalomyelitis
Antigen Presentation
Callithrix
Myelin-Associated Glycoprotein
medicine.anatomical_structure
Female
Myelin Proteins
Encephalomyelitis
Autoimmune
Experimental
Injections
Intradermal
T cell
Biology
Myelin oligodendrocyte glycoprotein
Cell Line
Injections
immunology/metabolism
administration /&/ dosage/immunology
Intradermal
medicine
Animals
Humans
Autoantibodies
etiology/immunology/pathology
Multiple sclerosis
Histocompatibility Antigens Class II
Myelin Basic Protein
medicine.disease
biology.organism_classification
Virology
Oligodendrocyte
Peptide Fragments
Myelin basic protein
nervous system diseases
nervous system
Immunology
biology.protein
Myelin-Oligodendrocyte Glycoprotein
Immunization
biosynthesis
Zdroj: Journal of Immunology, 165(2), 1093-1101. American Association of Immunologists
Journal of Immunology, 165, 1093-1101. American Association of Immunologists
ResearcherID
Scopus-Elsevier
ISSN: 0022-1767
DOI: 10.4049/jimmunol.165.2.1093
Popis: Immunization of common marmosets (Callithrix jacchus) with a single dose of human myelin in CFA, without administration of Bordetella pertussis, induces a form of autoimmune encephalomyelitis (EAE) resembling in its clinical and pathological expression multiple sclerosis in humans. The EAE incidence in our outbred marmoset colony is 100%. This study was undertaken to assess the genetic and immunological basis of the high EAE susceptibility. To this end, we determined the separate contributions of immune reactions to myelin/oligodendrocyte glycoprotein (MOG) and myelin basic protein to the EAE induction. Essentially all pathological features of myelin-induced EAE were also found in animals immunized with MOG in CFA, whereas in animals immunized with myelin basic protein in CFA clinical and pathological signs of EAE were lacking. The epitope recognition by anti-MOG Abs and T cells were assessed. Evidence is provided that the initiation of EAE is based on T and B cell activation by the encephalitogenic phMOG14–36 peptide in the context of monomorphic Caja-DRB*W1201 molecules.
Databáze: OpenAIRE
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