Recent advances in understanding and managing chordomas: an update
| Autor: | Valery Peinado-Reyes, Salah G. Aoun, Chen Shi, Scott Connors, Carlos A. Bagley, Kristen Hall |
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| Rok vydání: | 2020 |
| Předmět: |
Surgical resection
medicine.medical_specialty chordoma genetics medicine.medical_treatment Bone Neoplasms Review primary bone tumors Radiosurgery radiation therapy General Biochemistry Genetics and Molecular Biology Resection Targeted therapy Quality of life chordoma surgery Targeted Molecular Therapy Chordoma Medicine Humans General Pharmacology Toxicology and Pharmaceutics Intensive care medicine General Immunology and Microbiology business.industry General Medicine Limiting Articles medicine.disease targeted therapy Radiation therapy Quality of Life Neoplasm Recurrence Local business |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Chordomas are rare and difficult-to-treat tumors arising from the embryonic notochord. While surgery is the mainstay of treatment, and despite new techniques aimed at maximizing total tumoral resection, recurrence remains high and the probability of disease-free survival low. New breakthroughs in genetics, targeted molecular therapy, and heavy-particle beam therapy offer some promise as adjuvant treatments in addition to surgical resection. A multidisciplinary approach encompassing genetics, immunotherapy, radiation therapy, and surgery, at a facility experienced in the management of this complex disease, offers the best chance of survival and quality of life to patients while limiting the intrinsic morbidity of these treatments. |
| Databáze: | OpenAIRE |
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