Protection by trehalose of DNA from radiation damage
| Autor: | Kunihiko Hasegawa, Masahiro Uritani, Hiroe Yoshioka, Hiromu Kurosaki, Miyuki Hirasawa, Koichi Yoshinaga |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Sucrose
Disaccharide DNA Single-Stranded Radiation-Protective Agents Applied Microbiology and Biotechnology Biochemistry Sensitivity and Specificity Analytical Chemistry Ionizing radiation chemistry.chemical_compound Radiation Protection Irradiation Sugar Maltose Molecular Biology Electrophoresis Agar Gel Organic Chemistry Trehalose Dose-Response Relationship Radiation General Medicine Beta Particles chemistry Gamma Rays DNA Circular DNA Biotechnology DNA Damage |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 61(1) |
| ISSN: | 0916-8451 |
| Popis: | The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mM trehalose, DNA can be protected from about 4 times higher doses of beta- and gamma-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects. |
| Databáze: | OpenAIRE |
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