Identification of morphine in the rat adrenal gland
| Autor: | George B. Stefano, Yannick Goumon |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Rat Adrenal Gland Morphine Adrenal gland Endogeny Biology High-performance liquid chromatography Gas Chromatography-Mass Spectrometry Rats Sprague dawley Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure Internal medicine Adrenal tissue Adrenal Glands medicine Animals Gas chromatography–mass spectrometry Molecular Biology Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Brain research. Molecular brain research. 77(2) |
| ISSN: | 0169-328X |
| Popis: | Morphine was identified in rat adrenal extracts by reverse-phase HPLC, following liquid and solid extraction. All experiments were carefully performed to prevent exogenous morphine contamination. The morphine extracted from adrenal tissue (105.31 ng/g of wet adrenal gland) was identical to that of a morphine internal standard. The morphine corresponding HPLC fractions were further analyzed by gas chromatography-mass spectrometry and found to be identical to synthetic morphine. The study conclusively proves morphine is endogenous to the rat adrenal gland. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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