Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona
| Autor: | Riddha Das, Singyuk Hou, Daniel F. Moyano, Sung Tae Kim, Rubul Mout, Krishnendu Saha, Mehran Rahimi, Morteza Mahmoudi, Mahdieh Yazdani, Vincent M. Rotello, Farhad Rezaee |
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| Přispěvatelé: | Chemical and Pharmaceutical Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
Surface Properties General Physics and Astronomy Nanoparticle Metal Nanoparticles COAGULATION Protein Corona Nanotechnology CELLULAR UPTAKE 02 engineering and technology Surface engineering 010402 general chemistry surface functionality DENSITY-LIPOPROTEIN 01 natural sciences Article C4B-BINDING PROTEIN Corona (optical phenomenon) Mice DELIVERY protein corona Cations Macrophage Animals Humans APOPTOTIC CELLS General Materials Science Particle Size complement system Chemistry General Engineering Cationic polymerization IRON-OXIDE NANOPARTICLES 021001 nanoscience & nanotechnology 0104 chemical sciences Complement system macrophages INTERFACE RAW 264.7 Cells SIZE Colloidal gold gold nanoparticles Biophysics Gold 0210 nano-technology Hydrophobic and Hydrophilic Interactions Protein Binding |
| Zdroj: | Acs Nano, 10(4), 4421-4430. AMER CHEMICAL SOC |
| ISSN: | 1936-0851 |
| Popis: | Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages. |
| Databáze: | OpenAIRE |
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