Outcomes of kidney donors with sickle cell trait: A preliminary analysis

Autor: Sean A. Hebert, Nisarg V. Gandhi, Sanad Al‐Amin, Angelina R. Edwards, Dina N. Murad, Duc T. Nguyen, Edward A. Graviss, Hassan N. Ibrahim
Rok vydání: 2022
Předmět:
Zdroj: Clinical Transplantation. 36
ISSN: 1399-0012
0902-0063
DOI: 10.1111/ctr.14626
Popis: Most transplant centers do not screen kidney donor candidates for sickle cell trait (SCT) and many decline candidates with SCT since it may associate with kidney disease. We compared 17 kidney donors with SCT to propensity score matched donor controls on mortality, reduced eGFR, proteinuria and kidney failure. The prevalence of SCT in African American (AA) donors was 11 per 1000 compared to 73 per 1000 in non-donor AA. Donors with SCT were younger; 33 versus 35 years in controls, nine were AA, six were White, and two were listed as other or unknown ethnicities. After a follow-up period of 18.2 ± 10.5 years, the proportions of donors with SCT and controls who were alive, developed hypertension or cardiovascular disease were similar. No donor with SCT developed an eGFR30 mL/min/1.73 m
Databáze: OpenAIRE
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