Nongenomic Steroid-Triggered Oocyte Maturation: Of Mice and Frogs
| Autor: | Michelle Jamnongjit, Kristen Evaul, Melissa Rasar, Stephen R. Hammes, James Deng, Liliana Carbajal |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Receptors Steroid media_common.quotation_subject Clinical Biochemistry Ovary Biology Biochemistry Oogenesis Article Paracrine signalling Mice Xenopus laevis Endocrinology Internal medicine Follicular phase medicine Animals Testosterone Receptor Molecular Biology Ovulation media_common Pharmacology Organic Chemistry Oocyte Cell biology medicine.anatomical_structure Oocytes Female Luteinizing hormone |
| Popis: | Luteinizing hormone (LH) mediates many important processes in ovarian follicles, including cumulus cell expansion, changes in gap junction expression and activity, sterol and steroid production, and the release of paracrine signaling molecules. All of these functions work together to trigger oocyte maturation (meiotic progression) and subsequent ovulation. Many laboratories are interested in better understanding both the extra-oocyte follicular processes that trigger oocyte maturation, as well as the intra-oocyte molecules and signals that regulate meiosis. Multiple model systems have been used to study LH-effects in the ovary, including fish, frogs, mice, rats, pigs, and primates. Here we provide a brief summary of oocyte maturation, focusing primarily on steroid-triggered meiotic progression in frogs and mice. Furthermore, we present new studies that implicate classical steroid receptors rather than alternative non-classical membrane steroid receptors as the primary regulators of steroid-mediated oocyte maturation in both of these model systems. |
| Databáze: | OpenAIRE |
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