Lacrimal gland, cornea, and tear film in the NZB/NZW F1hybrid mouse
| Autor: | Laila A. Hanninen, Jeffrey P. Gilbard, Richard C. Rothman, Kenneth R. Kenyon |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Ratón Mice Inbred Strains Lacrimal gland Biology Cornea Mice Cellular and Molecular Neuroscience stomatognathic system Inbred strain medicine Animals KERATOCONJUNCTIVITIS SICCA Osmotic concentration Osmolar Concentration Lacrimal Apparatus medicine.disease Tear osmolarity eye diseases Sensory Systems Microscopy Electron Ophthalmology Sjogren's Syndrome medicine.anatomical_structure Tears Microscopy Electron Scanning Hybridization Genetic Female sense organs Infiltration (medical) |
| Zdroj: | Current Eye Research. 6:1237-1248 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.3109/02713688709025234 |
| Popis: | The NZB/NZW F1 hybrid mouse has been reported to contract a disease similar to Sjögren's syndrome in man. We studied lacrimal gland morphology, corneal morphology, and tear osmolarity in this mouse as a function of age. Lacrimal glands of hybrid mice contained abnormal periductal infiltrates of lymphocytes and plasma cells. Maximum infiltration of the lacrimal gland occurred in the 29-week-old female hybrid mouse and was estimated to involve 12% of the gland, but was insufficient to alter tear osmolarity relative to DBA and Balb/c control mice. Nevertheless, both NZB/NZW F1 hybrid mice and DBA and Balb/c control mice had tear osmolarity and corneal surface morphology similar to that reported for keratoconjunctivitis sicca in man. Although the NZB/NZW F1 hybrid mouse may provide a valuable model for the study of lacrimal gland infiltration, since its tear osmolarity and ocular surface remain normal for a mouse, its usefulness as a model for ocular surface disease in human keratoconjunctivitis sicca may be more limited than previously thought. |
| Databáze: | OpenAIRE |
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