Links between prolonged exposure to xenobiotics, increased incidence of hepatopathies, immunological disturbances and exacerbation of latent epstein-barr virus infections
| Autor: | A. Keleová, M. Oltman, G. Košecká, D Stancek, E. Jahnová |
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| Rok vydání: | 1995 |
| Předmět: |
Herpesvirus 4
Human Cellular immunity Time Factors Exacerbation Immunology Biology Antibodies Viral medicine.disease_cause Herpesviridae Virus Xenobiotics Immunocompromised Host Immune system Occupational Exposure hemic and lymphatic diseases medicine Humans Antigens Viral Epstein–Barr virus infection Respiratory Burst Retrospective Studies Pharmacology Immunity Cellular Models Immunological Herpesviridae Infections Oxidants medicine.disease Hepatitis C Epstein–Barr virus Respiratory burst Occupational Diseases Oxidative Stress Chemical Industry Antibody Formation Cytokines Environmental Pollutants Virus Activation Chemical and Drug Induced Liver Injury Electronics |
| Zdroj: | International Journal of Immunopharmacology. 17:321-328 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(95)00006-n |
| Popis: | Disturbances of several humoral and cellular immune parameters are significantly increased in individuals exposed to chemical pollutants. Moreover, exacerbations of the latent Epstein-Barr virus (EBV) infection were more frequently observed in the chemically exposed group than in the control groups. A significant correlation was seen between EBV exacerbations and the increased number of eosinophils, T-lymphocyte rosette formation and the respiratory burst of polymorphonuclear blood cells. Possible links between hepatopathy due to xenobiotics exposition, immunological disturbances and EBV exacerbation are discussed, including a putative role of EBV-induced (autocrine) cytokines. |
| Databáze: | OpenAIRE |
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