A Brain-Computer Interface Based Cognitive Training System for Healthy Elderly: A Randomized Control Pilot Study for Usability and Preliminary Efficacy
| Autor: | Yin Bun Cheung, Jimmy Lee, Haihong Zhang, Richard S.E. Keefe, Chuanchu Wang, Cuntai Guan, Stephanie Sze Wei Teng, Siau Juinn Alexa Goh, K. Ranga Rama Krishnan, Tze Pin Ng, Zheng Yang Chin, Shin Yi Quek, Tih-Shih Lee, Rachel Phillips, Lei Feng |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Repeatable Battery for the Assessment of Neuropsychological Status IMPACT General Science & Technology Science Pilot Projects NEUROFEEDBACK Cognition Quality of life Surveys and Questionnaires PROGRAM medicine Attention deficit hyperactivity disorder Humans Cognitive decline OLDER-ADULTS Aged Geriatrics Science & Technology Multidisciplinary business.industry MEMORY Usability Middle Aged medicine.disease Cognitive training Multidisciplinary Sciences Brain-Computer Interfaces Physical therapy Science & Technology - Other Topics Medicine TRIAL Female business Research Article |
| Zdroj: | PLoS ONE Lee, TS, Goh, SJA, Quek, SY, Phillips, R, Guan, C, Cheung, YB, Feng, L, Teng, SSW, Wang, CC, Chin, ZY, Zhang, H, Ng, TP, Lee, J, Keefe, R & Krishnan, KRR 2013, ' A Brain-Computer Interface Based Cognitive Training System for Healthy Elderly: A Randomized Control Pilot Study for Usability and Preliminary Efficacy ', PLOS One, vol. 8, no. 11 . https://doi.org/10.1371/journal.pone.0079419 PLoS ONE, Vol 8, Iss 11, p e79419 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0079419 |
| Popis: | UnlabelledCognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving symptoms of attention deficit hyperactivity disorder. Here, we examine the feasibility of the BCI system with a new game that incorporates memory training in improving memory and attention in a pilot sample of healthy elderly. This study investigates the safety, usability and acceptability of our BCI system to elderly, and obtains an efficacy estimate to warrant a phase III trial. Thirty-one healthy elderly were randomized into intervention (n = 15) and waitlist control arms (n = 16). Intervention consisted of an 8-week training comprising 24 half-hour sessions. A usability and acceptability questionnaire was administered at the end of training. Safety was investigated by querying users about adverse events after every session. Efficacy of the system was measured by the change of total score from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) before and after training. Feedback on the usability and acceptability questionnaire was positive. No adverse events were reported for all participants across all sessions. Though the median difference in the RBANS change scores between arms was not statistically significant, an effect size of 0.6SD was obtained, which reflects potential clinical utility according to Simon's randomized phase II trial design. Pooled data from both arms also showed that the median change in total scores pre and post-training was statistically significant (Mdn = 4.0; pTrial registrationClinicalTrials.gov NCT01661894. |
| Databáze: | OpenAIRE |
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