A20-OVA Nanoparticles Inhibit Allergic Asthma in a Murine Model
| Autor: | Li-Hua Mo, Jianwen Zhong, Yilong Zhou, Xiang-Qian Luo, Shuyao Qiu, Da-Bo Liu, Min Zhi, Ping-Chang Yang, Liqiang Yang, Fen-Xuan Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Ovalbumin Regulatory T cell Immunology macromolecular substances medicine.disease_cause T-Lymphocytes Regulatory Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer Antigen Ubiquitin immune system diseases hemic and lymphatic diseases medicine Animals Immunology and Allergy Tumor Necrosis Factor alpha-Induced Protein 3 Asthma Mice Inbred BALB C Dose-Response Relationship Drug biology business.industry technology industry and agriculture respiratory system medicine.disease Ubiquitin ligase Disease Models Animal 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Allergic response biology.protein Nanoparticles Female business Homeostasis |
| Zdroj: | Inflammation. 43:953-961 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-020-01181-5 |
| Popis: | The skewed T helper (Th) 2 response plays a critical role in the pathogenesis of allergic asthma. Regulatory T (Treg) cells and the regulatory cytokines are required in maintaining the homeostasis in the body. This study aims to determine the effects of a poly(lactic-co-glycolic) acid (PLGA)-ovalbumin (OVA)+A20 (a ubiquitin E3 ligase) nanovaccine on inhibiting allergic asthma in a murine model. In this study, A20 and OVA (a model antigen) were encapsulated into PLGA to be a nanovaccine (PLGA-OVA+A20). An allergic asthma murine model was developed with OVA as the specific antigen to test the role of PLGA-OVA+A20 nanovaccine in maintaining the immune homeostasis in the airway tissues. The results showed that PLGA-OVA+A20 nanovaccine inhibited the asthma responses in mice by suppressing Th2 inflammatory responses, promoting the generation of Treg cells in the airway tissues. We conclude that the PLGA-OVA+A20 nanovaccine has a marked inhibitory effect on the airway allergic response in sensitized mice by significantly promoting the generation of Treg cell and IL-10. The data suggest that PLGA-OVA+A20 has translational potential in the treatment of allergic asthma. |
| Databáze: | OpenAIRE |
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