Polymorphism+17 C/G in Matrix Metalloprotease MMP8 decreases lung cancer risk
| Autor: | Teresa Pascual, Xose S. Puente, Ana Fernández-Somoano, Patricia González-Arriaga, M Felicitas López-Cima, Adonina Tardón, Manuel G. Marrón |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Cancer Research Lung Neoplasms MMP1 Kaplan-Meier Estimate Biology Matrix metalloproteinase MMP8 lcsh:RC254-282 Polymerase Chain Reaction Extracellular matrix Matrix Metalloproteinase 13 Genetics medicine Humans Genetic Predisposition to Disease Promoter Regions Genetic Lung cancer Aged Basement membrane Models Statistical Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Matrix Metalloproteinase 8 medicine.anatomical_structure Oncology Spain Case-Control Studies Immunology Cancer research Collagenase Female Matrix Metalloproteinase 1 Stem cell Polymorphism Restriction Fragment Length Research Article medicine.drug |
| Zdroj: | WOS BMC Cancer RUO. Repositorio Institucional de la Universidad de Oviedo instname BMC Cancer, Vol 8, Iss 1, p 378 (2008) |
| Popis: | Background Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membrane. Polymorphisms in MMP genes may result in changes in the expression of MMPs being associated with the development and progression of cancer. We have investigated the association between three polymorphisms (-1607 1G/2G, +17 C/G and -77 A/G) in the human collagenases MMP1, MMP8 and MMP13 and the risk of development or progression of lung cancer. Methods A hospital-based case-control study was designed including 501 lung cancer patients and 510 controls matched. Genotypes were determined by PCR-RFLP. Results were analyzed using unconditional logistic regression, Cox's proportional hazard regression, and the Kaplan-Meier method. Results The MMP1 and MMP13 promoter polymorphisms were not associated with lung cancer risk, while the C/G polymorphism in MMP8 was associated with a statistically significant decreased risk of developing lung cancer (ORadj = 0.65; 95%CI = 0.45–0.93). The Kaplan-Meier analysis showed that the polymorphisms in MMP1, MMP8 and MMP13 not seem to modify the overall survival. Multivariate analysis revealed that MMP1, MMP8 and MMP13 polymorphisms are not independent prognostic factors for overall survival. Conclusion This study suggests that the polymorphism in MMP8 is associated with a decreased lung cancer risk, which can be used as a prognostic marker in lung cancer. |
| Databáze: | OpenAIRE |
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