Autor:	Alexander Kasal, Libor Matyas, Radek Pohl
Předmět:	Pharmacology chemistry.chemical_classification Ketone Complementary and alternative medicine chemistry Group (periodic table) Yield (chemistry) Drug Discovery Plant Science General Medicine Medicinal chemistry
Zdroj:	Scopus-Elsevier
Popis:	12,20-Dioxo-5α-pregnan-3β-yl acetate, obtained from hecogenin, was treated with NaH in DMSO to yield the bridged cyclopropano ketone, 3β-hydroxy-12α,21-cyclo-12β,21-methano-5α,17α-pregnan-20-one. In tert-BuOH the reaction leads to 3β-hydroxy-12,21-cyclo-5α-pregn-12,21-en-20-one. Experimental data prove that the new methylene group of the cyclopropane ring came from DMSO.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a12b9aec3db21d3623d586bd28d708a http://www.scopus.com/inward/record.url?eid=2-s2.0-84897489723&partnerID=MN8TOARS Zobrazit plný text záznamu