Biphasic GA 68-labeled prostate specific membrane antigen-11 positron emission tomography/computed tomography scans in the differential diagnosis and risk stratification of initial primary prostate cancer
| Autor: | Mu-Hua Cheng, Liang-Jun Xie, Luping Qin, Jin-Ping Li, Ming-Zhao Li, Jie Lv, Jianfang Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.diagnostic_test
Receiver operating characteristic business.industry Area under the curve Standardized uptake value urologic and male genital diseases medicine.disease Prostate cancer medicine.anatomical_structure Positron emission tomography Prostate medicine Original Article Radiology Nuclear Medicine and imaging Differential diagnosis Nuclear medicine business Prospective cohort study |
| Zdroj: | Quant Imaging Med Surg |
| ISSN: | 2223-4306 2223-4292 |
| DOI: | 10.21037/qims-20-1312 |
| Popis: | BACKGROUND: This study aimed to assess the value of biphasic GA 68-labeled prostate-specific membrane antigen-11 ((68)Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) scan in the differential diagnosis and risk stratification of initial primary prostate cancer (PCa). METHODS: A total of 51 patients with PCa (8 low- and intermediate-risk PCa patients and 43 high-risk PCa patients) and 36 patients with benign prostate lesions, who underwent standard whole-body imaging and delayed pelvic imaging of (68)Ga-PSMA-11 PET/CT, were enrolled in this prospective study. The PET parameters, such as maximum and mean standard uptake value (SUVmax and SUVmean), and maximum and mean standard retention index of PET images were calculated and compared in different prostate lesions. The diagnostic performances of the PET parameters were evaluated by receiver operating characteristic (ROC) curves. RESULTS: All the PET parameters of PCa participants were significantly higher than those of participants with benign prostate lesions (P |
| Databáze: | OpenAIRE |
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