Evolution of Yeast Noncoding RNAs Reveals an Alternative Mechanism for Widespread Intron Loss
| Autor: | Quinn M. Mitrovich, Brian B. Tuch, Christine Guthrie, Alexander D. Johnson, Francisco M. De La Vega |
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| Rok vydání: | 2010 |
| Předmět: |
RNA Splicing
Saccharomyces cerevisiae Biology Article Evolution Molecular Exon SnoRNA processing Minor spliceosome Yeasts Candida albicans RNA Small Nucleolar Small nucleolar RNA Genetics Multidisciplinary Sequence Analysis RNA Intron Molecular Sequence Annotation RNA Fungal Exons Group II intron Non-coding RNA Introns Alternative Splicing RNA splicing RNA Splice Sites Genome Fungal |
| Zdroj: | Science. 330:838-841 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1194554 |
| Popis: | Kicking Out Introns Many genes in eukaryotes contain introns that must be removed from the messenger RNA for proper gene function. Humans have on average eight introns per gene, whereas more than 90% of the genes in the yeast species Saccharomyces cerevisiae and Candida albicans have none at all. To understand how introns can be lost from genes, Mitrovich et al. (p. 838 ) compared non–protein-coding genes among the yeasts and found that genes for small nucleolar RNAs (snoRNAs) in C. albicans are intronic. By contrast in S. cerevisiae , snoRNAs are processed from unmodified RNA, suggesting a massive loss of snoRNAs—associated introns in the common ancestor of the Saccharomyces species. The introns seem to have been lost through splice-site degeneration, and associated compaction of linked exons resulted in nested splicing of some snoRNAs. |
| Databáze: | OpenAIRE |
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