Smoking Cessation Rapidly Increases Circulating Progenitor Cells in Peripheral Blood in Chronic Smokers
| Autor: | Koichi Kobayashi, Kyosuke Takeshita, Mutsuharu Hayashi, Takahisa Kondo, Yasushi Numaguchi, Yasuya Inden, Toyoaki Murohara, Shigeo Iino |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Angiogenesis medicine.medical_treatment CD34 Antigens CD34 Leukocyte Count Antigens CD Risk Factors Internal medicine medicine Humans AC133 Antigen Progenitor cell Inverse correlation Triglycerides Glycoproteins Inflammation Vascular disease business.industry Smoking Mesenchymal Stem Cells Flow Cytometry medicine.disease Peripheral blood Blood Cell Count Endothelial stem cell Cholesterol Endocrinology Cardiovascular Diseases embryonic structures cardiovascular system Leukocyte Common Antigens Smoking cessation Smoking Cessation Peptides Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 24:1442-1447 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000135655.52088.c5 |
| Popis: | Objective— Circulating endothelial progenitor cells (EPCs) contribute to postnatal angiogenesis. The number of circulating EPCs has an inverse correlation with coronary risk scores. However, the effect of smoking on the number of circulating EPCs is not well-known. Methods and Results— We examined the effects of chronic smoking and of smoking cessation on EPC levels. Circulating EPCs were quantified by flow cytometry as CD45 low CD34 + CD133 + (progenitor cells [PCs]) or CD45 low CD34 + CD133 + VEGFR2 + (EPCs) in 14 nonsmokers and in 15 smokers. All smokers quit smoking. Eight quit smoking with nicotine patch and 7 without nicotine patch. PC/EPC levels were inversely correlated with the number of cigarettes smoked. Circulating PCs/EPCs increased rapidly after cessation ( P P =0.0031). The magnitude of increase in EPCs was greater in light smokers than in heavy smokers. Conclusions— The number of circulating PCs/EPCs was reduced in chronic smokers. Smoking cessation led to a rapid restoration of PC/EPC levels. The recovery of EPC levels was greater in light smokers than in heavy smokers. The decreased number of circulating EPCs would make smokers susceptible to cardiovascular disease, and even short-time cessation of smoking may be an effective means to reduce cardiovascular risk. |
| Databáze: | OpenAIRE |
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