The effects of Xenon gas inhalation on neuropathology in a placental-induced brain injury model in neonates: A pilot study
| Autor: | David A. Menassa, Marianne Thoresen, Thomas E. Phillips, Simon Grant, Nicki Cohen |
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| Rok vydání: | 2020 |
| Předmět: |
Xenon
cooling placental reprogramming chemistry.chemical_element Pilot Projects Neuropathology Hypoxic ischaemic encephalopathy Hypothermia Induced Pregnancy Medicine Humans Asphyxia Neonatorum neurodevelopment business.industry Infant Newborn General Medicine brain injury hypoxic-ischaemic encephalopathy chemistry Anesthesia Brain Injuries Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain Female Injury model Gas inhalation business |
| Zdroj: | Phillips, T, Menassa, D A, Grant, S, Cohen, N & Thoresen, M 2020, ' The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates : A Pilot Study ', Acta Paediatrica . https://doi.org/10.1111/apa.15486 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.15486 |
| Popis: | Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic-ischemic-encephalopathy (HIE), however 1-3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors. |
| Databáze: | OpenAIRE |
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