Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals
| Autor: | Moacir Fernandes Queiroz, Hugo Alexandre Oliveira Rocha, Jailma Almeida-Lima, Karoline Rachel Teodosio Melo, Camila Renata Machado Lima, Raniere Fagundes Melo-Silveira, Arthur Anthunes Jacome Vidal, Rafael Barros Gomes Camara |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
Free Radicals Iron medicine.medical_treatment Calcium oxalate Pharmaceutical Science Iron Chelating Agents Phaeophyta medicine.disease_cause Polysaccharide Article Antioxidants Analytical Chemistry law.invention lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Polysaccharides law Spectroscopy Fourier Transform Infrared Drug Discovery medicine bioactive polysaccharides Organic chemistry Physical and Theoretical Chemistry Crystallization Chelating Agents Glucan chemistry.chemical_classification Calcium Oxalate Chemistry urolithiasis Organic Chemistry glucan Seaweed In vitro Liquid Crystals fucan Chemistry (miscellaneous) Molecular Medicine Sulfated polysaccharides Oxidation-Reduction Copper Oxidative stress |
| Zdroj: | Molecules; Volume 18; Issue 12; Pages: 14543-14563 Molecules Molecules, Vol 18, Iss 12, Pp 14543-14563 (2013) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules181214543 |
| Popis: | Oxalate crystals and other types of crystals are the cause of urolithiasis, and these are related to oxidative stress. The search for new compounds with antioxidant qualities and inhibitors of these crystal formations is therefore necessary. In this study, we extracted four sulfated polysaccharides, a fucoglucoxyloglucuronan (DJ-0.3v), a heterofucan (DJ-0.4v), and two glucans (DJ-0.5v and DJ-1.2v), from the marine alga Dictyopteris justii. The presence of sulfated polysaccharides was confirmed by chemical analysis and FT-IR. All the sulfated polysaccharides presented antioxidant activity under different conditions in some of the in vitro tests and inhibited the formation of calcium oxalate crystals. Fucan DJ-0.4v was the polysaccharide that showed the best antioxidant activity and was one of the best inhibitors of the crystallization of calcium oxalate. Glucan DJ-0.5v was the second most potent inhibitor of the formation of oxalate crystals, as it stabilized dehydrated oxalate crystals (less aggressive form), preventing them from transforming into monohydrate crystals (more aggressive form). The obtained data lead us to propose that these sulfated polysaccharides are promising agents for use in the treatment of urolithiasis. |
| Databáze: | OpenAIRE |
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