Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
| Autor: | Corinne Garbar, Philippe Valet, Laurent Martiny, Christian Garbar, Cédric Dray, Alizée Dortignac, Béatrice Romier, Laurent Duca, Thinhinane Hocine, Amar Bennasroune, Camille Boulagnon, Sébastien Blaise, Hervé Sartelet, Laetitia Vanalderwiert, Amandine Wahart, Pascal Maurice, Nicole Bouland |
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| Přispěvatelé: | Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Geroscience and rejuvenation research center (RESTORE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Jean Godinot [Reims], UNICANCER, MAURICE, Pascal |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Science [SDV]Life Sciences [q-bio] Cardiology Gene Expression Adipose tissue Blood Pressure Diseases Pathogenesis White adipose tissue Article Extracellular matrix Mice chemistry.chemical_compound Vascular Stiffness Endocrinology Adipocyte Internal medicine medicine.artery medicine Animals Aorta Cathepsin S Mice Knockout Multidisciplinary Pancreatic Elastase business.industry Immunohistochemistry Extracellular Matrix Apelin [SDV] Life Sciences [q-bio] Risk factors chemistry Medicine Aortic stiffness business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, 2021, 11, ⟨10.1038/s41598-021-01735-z⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Numerous recent studies have shown that in the continuum of cardiovascular diseases, the measurement of arterial stiffness has powerful predictive value in cardiovascular risk and mortality and that this value is independent of other conventional risk factors, such as age, cholesterol levels, diabetes, smoking, or average blood pressure. Vascular stiffening is often the main cause of arterial hypertension (AHT), which is common in the presence of obesity. However, the mechanisms leading to vascular stiffening, as well as preventive factors, remain unclear. The aim of the present study was to investigate the consequences of apelin deficiency on the vascular stiffening and wall remodeling of aorta in mice. This factor freed by visceral adipose tissue, is known for its homeostasic role in lipid and vascular metabolisms, or again in inflammation. We compared the level of metabolic markers, inflammation of white adipose tissue (WAT), and aortic wall remodeling from functional and structural approaches in apelin-deficient and wild-type (WT) mice. Apelin-deficient mice were generated by knockout of the apelin gene (APL-KO). From 8 mice by groups, aortic stiffness was analyzed by pulse wave velocity measurements and by characterizations of collagen and elastic fibers. Mann–Whitney statistical test determined the significant data (p |
| Databáze: | OpenAIRE |
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